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| Tec-Control Chromatography |
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For radiopharmaceutical quality control
Tec-Control Chromatography tests the radiochemical purity of specific
Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows
which strips and solvents are
required to perform each individual
test. Some solvents must be purchased separately
(see Sigma-Aldrich
chart) due to hazardous material shipping restrictions.
Detailed
instruction manuals are packaged with each strip container, although
our
Radiopharmaceutical QC Procedure Manual (151-000) explains
paper chromatography
in greater detail.
Simple 3-step procedure
The Aluminum Breakthru Kit provides a rapid, easy and inexpensive
way to test aqueous
solutions, particularly pertechnetate generator
eluate, for trace quantities of aluminum.
Aluminum forms an intense
red precipitate with the indicator paper, and the intensity of
the
color is directly proportional to the amount of aluminum in
the solution. The USP allows a
concentration of aluminum ion in
an injection ≤10 micrograms per milliliter (10 µg/ml)
in
technetium 99m eluate prepared from Molybdenum 99 formed as
a result of uranium fission.
Simple Procedure:
| 1. |
Place a drop of the eluate or solution
to be tested on the indicator paper.
The best procedure is
to form a hanging drop using a 19-22G needle. |
| 2. |
Place a drop of the standard aluminum
solution on the indicator paper.
Use the same size drop. |
| 3. |
Compare the intensity of the red spot
formed. If the eluate spot is less intense
than the standard
solution, the eluate contains less than 10µg/ml aluminum. |
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| 150-780 |
Chromatography
Kit, Tec-Control
Aluminum Breakthru Kit includes:
Aluminum standard, 5 ml, 10 ug/ml,
50 indicator strips and manual |
$65.00 |
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| 151-000 |
Procedure Manual,
Radiopharmaceutical QC |
16.95 |
|
Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals;
A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977,
pg. 1230.
Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis,
A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center,
Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1. |
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This 90-page manual explains Paper Chromatography,
a QC method for evaluating the radiochemical purity of currently used Tc-99m-labeled
radiopharmaceuticals. Procedures are quick and easy to use, a simple quality
control solution for any nuclear medicine department.
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| RADIOPHARMACEUTICAL |
SOLVENT(S)
REQUIRED* |
STRIPS REQUIRED |
| Aluminum Breakthru |
150-781 |
150-782 |
| Bicisate (Neurolite™) |
Ethyl Acetate 99.% |
150-130 |
| Diphosphonate |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| Disofenin (Hepatolite™) |
150-160, Distilled
H2O |
150-122 & 150-125 |
| DMSA |
Acetone (HPLC Grade), |
150-025 |
| DTPA |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| Exametazine (Ceretec™) |
Ethyl Acetate 99.% |
150-130 |
| Glucoheptonate |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| HDP |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| MAA |
Acetone (HPLC Grade), |
150-001 |
| MAG3 (Mertiatide™) |
Acetone, (HPLC
Grade),
Chloroform 99.8%
Tetrahydrofuran 99+% |
150-951 & 150-952 |
| MDP |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| Mebrofenin (Cholotec™) |
150-160, Distilled
H2O |
150-122 & 150-125 |
| Pyrophosphate |
Acetone (HPLC Grade),
Distilled H2O |
150-001 & 150-005 |
| Sestamibi (Cardiolite™ and
Miraluma™ |
Ethyl Acetate 99.% |
150-991 |
| Sulphur Colloid |
Acetone (HPLC Grade) |
150-001 |
| Tc-99m (reduced) |
Acetone (HPLC Grade), |
150-001 |
| Tc-99m Monocolonal
Antibodies |
0.9% Saline |
150-771 |
| Tetrofosmin (Myoview™) |
Ethyl Acetate 99.% |
150-971 |
| In-111, Octreotide
(Octreoscan™) |
150-773 & 0.9%
Saline |
150-771 ** |
| In-11 Monocolonal
Antibodies |
150-773 & 0.9%
Saline |
150-771 ** |
| In-111/Y-90 Zevalin™ |
150-773 & 0.9%
Saline |
150-771 |
I-131 Monoclonal
Antibodies
And Neutrospec™ |
0.9% Saline |
150-771 |
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| * See Sigma-Aldrich product
matrix for solvents. |
| ** Note: A Well Plate is suggested
to perform QC on these radiopharmacuticals |
| |
Contact Fisher Scientific Corp.
800-766-7000 / www.fishersci.com /
Item #14-245-71 |
Chromatography Strips
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| 150-001 |
Strips, RED,
50/pkg |
$33.00 |
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| 150-005 |
Strips, BLACK,
50/pkg |
43.00 |
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| 150-025 |
Strips, YELLOW,
50/pkg |
54.00 |
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| 150-122 |
Strips, ORANGE,
50/pkg |
43.00 |
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| 150-125 |
Strips, LIGHT
BLUE, 50/pkg |
43.00 |
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| 150-130 |
Strips, GOLD,
50/pkg |
50.00 |
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| 150-771 |
Strips, DARK
GREEN, 50/pkg |
45.00 |
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| 150-951 |
Strips, LIME,
50/pkg |
45.00 |
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| 150-952 |
Strips, PEACH,
50/pkg |
45.00 |
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| 150-971 |
Strips, TEAL,
50/pkg |
50.00 |
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| 150-991 |
Strips, PINK,
50/pkg |
50.00 |
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| 150-782 |
Strips, ALUMINUM,
50/pkg |
35.00 |
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Chromatography Solvents
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| 150-160 |
Solvent, 20%
Sodium Chloride, 30 ml |
$25.00 |
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| 150-773 |
Solvent, DTPA,
5 ml |
25.00 |
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| 150-781 |
Solvent, Aluminum
Standard, 5 ml, 10 µg/ml |
35.00 |
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Related Items:
|
| 150-960 |
Developing Vials, 10 ml, 288/case
(used for all Tec-Control testing) |
$250.00 |
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| 150-961 |
Developing Vials, 5 ml, 144/case
(used for Sestamibi & Tetrofosmin) |
100.00 |
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| 066-533 |
Forceps, Curved, Locking, 9.5" l
(24.1 cm) |
32.00 |
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| 066-535 |
Forceps, Straight, Locking, 9.5" l
(24.1 cm) |
32.00 |
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| 066-536 |
Forceps, Curved, Non-Locking,
13.5" l (34.3 cm) |
48.00 |
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Tec-Control Solvent Vendor:
Sigma-Aldrich Chemical Company
800-558-9160 / www.sigmaaldrich.com
Note: Customers outside the US should visit Sigma-Aldrich
web site
to locate a regional office. |
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| Acetone HPLC Grade |
27072-5 |
| Ethyl Acetate 99.5%
ACS Reagent |
31990-2 |
| Chloroform 99.8% ACS
Reagent |
31998-8 |
| Tetrahydrofuran 99+%
ACS Reagent |
36058-9 |
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